Narcolepsy is a sleep disorder that affects 1 in every 2000 people in the US, which means it has caused approximately 200,000 Americans and 3 million people online problems. This disorder is caused by excessive sleepiness, sudden loss of muscle tone like cataplexy and many other sleep related symptoms. ( Source: Narcolepsy network).

Now as we are in 2024 it has now become important for us to cure narcolepsy not only for improving the quality of life for people living with this condition but also to address the rising concern for this disorder.

 In this blog we will try to cover the top 3 ways to cure narcolepsy permanently in 2024 which includes promising development in the field of orexin receptor agonists, medications and natural treatments like biofeedback therapy and meditation. You will also learn about how these medications for narcolepsy treatment works, their effectiveness and long-term success in treating this complex disorder.

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Understanding Narcolepsy with its causes and symptoms 

Narcolepsy is a chronic neurological disorder which can control the ability of your brain and can affect your sleep-wake cycles. If you or someone you know is suffering from Narcolepsy then you may have this symptom of feeling rested after waking up but then again feel sleepy throughout your day. Many individuals also face uneven sleep patterns and frequently wake up during the night. As disruptive as this condition sounds, its treatment usually responds well. 

Till date the research is going on to understand the exact cause of narcolepsy but it is still unknown. You can have narcolepsy if your brain is deficient in a chemical called hypocretin or orexin. 

  • Hypocretin- The role of hypocretin is to regulate the sleep and wake cycle and this chemical is usually low in individuals who face cataplexy. 

Some of the common symptoms of narcolepsy include excessive daytime sleeping, sudden sleep attacks, sleep paralysis and hallucinations. People between the age of 10-30 years can face this condition and also those who have their family history in this disorder. 

Top 3 Permanent Treatment for Cure Narcolepsy 

Here is the list of top 3 treatments that can potentially cure your narcolepsy permanently:

1. Orexin Receptors 2 Agonists 

They are a new class of drugs which target the orexin system in our brain. In our sleep cycles the orexin system plays a major role and a dysfunction in it is believed to be a main cause of narcolepsy. 

If used properly the orexin receptors 2 can effectively promote wakefulness in you and can also reduce excessive daytime sleepiness. The main orexin receptors that are used for the treatment of narcolepsy are:

  • Tak-881- The Tak-881 is a therapeutic profile under the orexin 2 receptor agonist which provides a sustained wakefulness in you throughout your day and addresses the long-term treatment for narcolepsy. 
  • Lemborexant (E2006)- This is a dual orexin receptor which is used in clinical trials for the treatment of sleep disorders. It can show promising results to you in the case of sleeping disorders like insomnia. However, more is needed to understand its complete efficacy and safety.
  • Daridorexant ( ACT-541468)- This is a drug which is also used in the clinical practices for narcolepsy. Darudorexant is approved in the US for the treatment of adults with insomnia.

2.  Take good medications 

Another permanent solution for narcolepsy is to take medications as it will help you to start a journey of a good quality life. People believe that medical treatments are the ultimate cure of narcolepsy and some of these medications are mentioned below:

(i) Stimulants

Stimulants are those type of drugs that stimulates in your nervous system and send signals to your brain so that it can stay awake during the day, The two commonly prescribed stimulants are:

  • Modafinil (Provigil)- This promotes wakefulness effects in a person (Buy modfinil online)
  • Armodafinil (Nuvigil)- It is similar to modafinil but lasts longer.

(ii) Antidepressants

The antidepressants work on cataplexy and all other emotional aspects of narcolepsy. These medications give signals to your brain to fight rapid eye movement (REM) sleep so that it can remove symptoms of narcolepsy like hallucinations and sleep paralysis. 

One of the most used antidepressants in the case of cure narcolepsy is fluoxetine.

3. Natural treatments with self-care tip

You can incorporate different natural and self-care tips to Cure narcolepsy and here are some of the effective approaches to do so:

(i) Biofeedback therapy  

The biofeedback tries to control the physiological functions and uses the real-time feedback. This type of technique will teach your body responses on how you can manage stress, anxiety and other symptoms related to narcolepsy.

By practicing this technique you will get relaxation, reduced muscle tension and great sleep quality. 

(ii) Guided Imagery Meditation 

It is a relaxation technique that uses your mental visualization to promote calmness and reduce stress in your body. During this type of meditation you create mental images of peaceful scenes or positive experiences which alleviate your anxiety and reduce the effect of sleep paralysis. 


While the above are some of the most common practices used to cure narcolepsy, in addition to this you can also try to change your dietary habits and can also add other physical activities like yoga and deep breathing in your life to make yourself better. 
Also Read : Is Modafinil Right for You? Understanding the Benefits and Risks of Modafinil?